Table 2.
Frequency of hematopoietic cell transplantation (HCT) in patients with AML
| All patients n (%) | ≤ 60 years, n (%) | > 60 years, n (%) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 1621 | 740 | 881 | |||||||
| Disease stage | CR1 | Refractory | Relapse/CR2 | CR1 | Refractory | Relapse/CR2 | CR1 | Refractory | Relapse/CR2 |
| n | 1144 | 238 | 582/227 | 586 | 56 | 235/128 | 558 | 182 | 347/99 |
| HCT | 427 (37.3) | 72 (30.2) | 155 (26.6/68.3) | 273 (46.6) | 39 (69.6) | 108 (46.0/84.4) | 154 (27.6) | 33 (18.1) | 47 (13.8/47.4) |
| Allogeneic HCT | 395 (92.5) | 72 | 151 (97.4) | 241 (88.3) | 39 | 107 (99.1) | 154 (100) | 33 | 44 (93.6) |
| Related donor | 112 (28.4) | 20 (27.8) | 23 (15.2) | 82 (34.0) | 12 (30.8) | 18 (17.5)* | 30 (19.5) | 8 (24.2) | 5 (11.4)# |
| Unrelated donor | 282 (71.4) | 51 (70.8) | 124 (82,1) | 158 (66.1) | 26 (66.7) | 86 (82.6)* | 124 (80.6) | 25 (75.8) | 38 (86.4)# |
| MMUD | 77 (27.3) | 16 (31.4) | 41 (33.1) | 41 (25.9) | 9 (34.6) | 36 (42.3)** | 36 (29.0) | 7 (28.0) | 5 (13.1)## |
| NMAC | 164 (41.5) | 14 (19.4) | 39 (25.8) | 44 (18.3) | 5 (12.8) | 21 (19.6) | 120 (77.9) | 9 (27.3) | 18 (40.9) |
| Autologous HCT | 32 (7.5) | - | 4 (2.6) | 32 (11.7) | - | 1 (0.9) | - | - | 3 (6.4) |
Information missing on: *3 donors, **9 × HLA matching, #1 donor, and ##1 × HLA matching missing
Abbreviations: MMUD, mismatched donor; NMAC, non-myeloablative conditioning HCT