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. 2021 May 15;142(3):495–511. doi: 10.1007/s00401-021-02324-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Validation of the separation between PD and MSA by the ratio between α-syn concentrations in putative oligodendroglial and neuronal exosomes. a The ratio between the α-syn concentration in putative oligodendroglial and neuronal exosomes was calculated for each sample and log-transformed. The data are presented as mean ± SD. The dashed line indicates the cutoff at 0 (log1). P values were calculated using a one-way ANOVA with post hoc Tukey test. b ROC analysis of the oligodendroglial:neuronal exosome α-syn ratio