Table 1.
Demographic and clinical data for final discovery cohort
| All samples | Control | PD | MSA (C:P) | |
|---|---|---|---|---|
| Total samples | 131 | 50 | 51 | 30 (26:4) |
| Agea (range) | 66.3 ± 11.1 (35–90) | 63.2 ± 12.2 (35–86) | 71.5 ± 9.5 (37–90) | 62.7 ± 8.3 (46–79) |
| Sex (male:female) | 67:64 | 22:28 | 32:19 | 13:17 |
| Disease duration in yearsa (range) | 7.0 ± 4.7 (0–19) | 8.4 ± 5.0 (0–19) | 4.4 ± 2.6 (0–10) | |
| Race/ethnicityb | Asc – 8 | As – 1 | As – 0 | As – 7 |
| B – 2 | B – 0 | B – 1 | B – 1 | |
| H – 6 | H – 4 | H – 1 | H – 1 | |
| HN – 14 | HN – 6 | HN – 8 | HN – 0 | |
| NA – 3 | NA – 2 | NA – 1 | NA – 0 | |
| ND – 2 | ND –1 | ND –0 | ND –1 | |
| W – 96 | W – 36 | W – 40 | W – 20 | |
| UPDRSd motor (range) | 25.4 ± 15.3 (0–59) | |||
| H&Yd (range) | 2.7 ± 1.1 (1–5) | 2.5 ± 1.0 (1–5) | 3.8 ± 1.0 (2–5) | |
| MMSEd (range) | 26.5 ± 6.2 (0–30) | 26.5 ± 9.3 (10–30)e |
aMean ± SD. bAs—Asian; B—Black; H—Hispanic; HN—Hispanic, non-White; NA—Native American, ND—non-disclosed; W—White. cKorea—2, Philippines—1, Taiwan—1, Vietnam—1, Undefined Asian—3. dUPDRS—Unified Parkinson’s disease rating scale, H&Y—Höhn and Yahr rating scale, MMSE—Mini-Mental State Examination. eConverted from Montreal Cognitive Assessment (MoCA) according to Lawton et al. [36]