Table 2.
Adjusted geometric means of uric acid metabolism by quartiles of UEGL (n = 635)
| Categories | UEGL category | P for trend a | |||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | ||
| Range (g/24 h) | 0.01–0.59 | 0.61–4.03 | 4.07–12.43 | 12.51–57.08 | – |
| No. of participants | 159 | 159 | 158 | 159 | – |
| SUA (μmol/L) | 324.8 (312.1–338.0)b | 298.1 (287.0–309.7)c | 290.4 (279.5–301.7)d | 284.6 (273.2–296.5)d | 0.0001 |
| UEUA (mg/24 h/1.73 m2) | 280.22 (251.84–311.80) | 315.35 (284.86–349.10) | 305.70 (275.95–338.65) | 362.41 (324.79–404.39)e | 0.26 |
| CLUA (mL/min/1.73 m2) | 3.60 (3.31–3.91) | 4.51 (4.17–4.88)d | 4.57 (4.23–4.95)d | 5.15 (4.73–5.60)f | < 0.0001 |
UEGL urinary excretion rate of glucose, SUA serum uric acid, UEUA urinary excretion rate of uric acid, CLUA renal clearance of uric acid, Q1 quartile 1 (P0, P25), Q2 quartile 2 (P25, P50), Q3 quartile 3 (P50, P75), Q4 quartile 4 (P75, P100)
a Analysis of covariance; Adjusted for sex, age, body mass index, diabetes mellitus duration, smoking, hypertension, haemoglobin A1c, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and estimated glomerular filtration rate. Test for trend based on variable containing median value for each quartile
b Adjusted geometric mean (95% confidence interval) (all such values)
c Significantly different from SUA of Q1, P = 0.02 (Bonferroni-corrected)
d Significantly different from SUA, UEUA, and CLUA of Q1, respectively, P < 0.001 (Bonferroni-corrected)
e Significantly different from UEUA of Q1, P = 0.01 (Bonferroni-corrected)
f Significantly different from CLUA of Q1, P < 0.0001 (Bonferroni-corrected)