Table 3.

Suggested RRT prescriptions for patients with metformin associated lactic acidosis

	Indications	References
Start of RRT	Lactic acid concentration > 20 mmol/L pH ≤ 7.0, shock, failure of standard supportive measures or decreased level of consciousness	[41, 49]
Timing of RRT	Early as soon as possible	[45, 50]
Duration of RRT	Continuous, or at least prolonged	[41, 45, 48, 50–52]
Dialysis dose (ml/Kg/day)	> 25 ml/Kg/hour (35–50??)	[45, 50]
RRT with bicarbonate solution	Yes, > 32 mmol/L	[41, 45, 49]
RRT modality	Diffusive, convective or mixed	[41, 45, 48–52]
Cessation of RRT	When lactate concentration is < 3 mmol/L and pH is > 7.35	[49]

RRT renal replacement therapy