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. 2021 Mar 13;268(9):3421–3434. doi: 10.1007/s00415-021-10504-x

Table 1.

Description of the study cohort

Patients with
Healthy subjects Vestibular disorders Cerebellar disorders Functional disorders Hypokinetic disorders Vascular disorders Others All ANOVA
Demographical characteristics F(6; 365) p
 n (f/m) 63 (31/32) 88 (39/49) 93(35/58) 50 (29/21) 22 (12/10) 55 (35/20) 25 (12/13) 396
 Mean age ± SD [y] 49 ± 14 58 ± 18 57 ± 18 46 ± 18 67 ± 16* 53 ± 17 51 ± 19 53 ± 18 2.1 0.043
 Diagnoses

48 BVP

40 UVP

14 SCA

11 FRDA

11 EA2

18 DBN

36 SAOA

1 ARAC

1 ACM

1 post stroke

34 PPPD

16 FGD

8 IPS

4 MSA

10 PSP

51 CADASIL

4 SAE

5 BPPV

1 ED

1 EC

2 HSP

1 Liquor leakage

3 NPc

1 stroke

11 VM

Clinical Performance Scales
 Median FGA ± SD [points] 29 ± 3 24 ± 5* 21 ± 6* 27 ± 4 17 ± 4* 26 ± 4 26 ± 4 25 ± 5 23.9  < 0.001
 Mean TUG ± SD [sec] 8.8 ± 3.2 9.1 ± 2.3 11.2 ± 7.1 9.0 ± 2.0 13.7 ± 7.5 9.3 ± 2.6 9.9 ± 3.5 9.9 ± 6.5 2.0 n.s
 Median MOCA ± SD [points] 29 ± 3 26 ± 4 24 ± 6* 26 ± 3 24 ± 8* 24 ± 4* 29 ± 15 26 ± 9 2.9 0.008
Subjective symptom scales
 Mean ABC-d ± SD [%] 95 ± 9 70 ± 23* 63 ± 22* 79 ± 21* 48 ± 28* 84 ± 21* 81 ± 25* 76 ± 24 22.2  < 0.001
 Median FES-I ± SD [points] 17 ± 2 24 ± 9* 31 ± 13* 25 ± 8* 42 ± 19* 21 ± 7* 31 ± 13* 26 ± 12 19.1  < 0.001
 Mean of SF-12 ± SD [points] physical domain 54 ± 6 40 ± 9* 38 ± 8* 38 ± 10* 33 ± 11* 47 ± 10* 40 ± 11* 43 ± 11 26.6  < 0.001
 Mean of SF-12 ± SD [points] psychological domain 52 ± 9 48 ± 12 48 ± 11 44 ± 12* 38 ± 13* 47 ± 12 47 ± 10 47 ± 11 4.5  < 0.001
Retrospective falls epidemiology df χ2 p
 No falls [%] 90 58 34 81 14 74 46 60 12 104.5  < 0.001
 Occasional fall [%] 7 23 23 15 9 11 27 17
 Frequent falls [%] 3 18 43 4 76 15 27 23
Retrospective falls severity
 Hopkins grade I [%] 45 47 24 58 10 34 29 36 24 154.5  < 0.001
 II [%] 27 27 49 29 35 53 58 40
 III [%] 27 13 15 11 20 0 0 12
 IV [%] 0 12 12 0 35 11 11 12

Sociodemographic, clinical information, and retrospective fall events (within 6 months) of the enrolled participants. Inter-subgroup differences are analyzed by ANOVA models with Sheffé post hoc comparisons (for sociodemographic and clinical data) and by χ2 procedures (fall data)

*Significant difference in the Sheffé post hoc comparison (compared to healthy subjects)

f female, m male, FGA functional gait assessment, FES-I falls efficacy scale-international, TUG timed-up-and-go test, MOCA Montreal Cognitive Assessment, SF-12 short form 12, BVP bilateral vestibular failure, UVP unilateral vestibular failure, SCA spinocerebellar ataxia, FRDA Friedreich ataxia, EA2 episodic ataxia type 2, DBN downbeat nystagmus syndrome, SAOA sporadic adult onset ataxia, ARAC autosomal recessive cerebellar ataxia, ACM tumor cerebellar, PPPD Persistent Phobic Postural Dizziness, FGD anxious functional gait disorder, CADASIL Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, SAE subcortical arteriosclerotic encephalopathy, BPPV benign paroxysmal positional vertigo, ED encephalomyelitis disseminate, HSP hereditary spastic paraplegia, NPc Niemann Pick Disease Type c, VM vestibular migraine