Table 1.
Patients with | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Healthy subjects | Vestibular disorders | Cerebellar disorders | Functional disorders | Hypokinetic disorders | Vascular disorders | Others | All | ANOVA | |||
Demographical characteristics | F(6; 365) | p | |||||||||
n (f/m) | 63 (31/32) | 88 (39/49) | 93(35/58) | 50 (29/21) | 22 (12/10) | 55 (35/20) | 25 (12/13) | 396 | – | – | |
Mean age ± SD [y] | 49 ± 14 | 58 ± 18 | 57 ± 18 | 46 ± 18 | 67 ± 16* | 53 ± 17 | 51 ± 19 | 53 ± 18 | 2.1 | 0.043 | |
Diagnoses |
48 BVP 40 UVP |
14 SCA 11 FRDA 11 EA2 18 DBN 36 SAOA 1 ARAC 1 ACM 1 post stroke |
34 PPPD 16 FGD |
8 IPS 4 MSA 10 PSP |
51 CADASIL 4 SAE |
5 BPPV 1 ED 1 EC 2 HSP 1 Liquor leakage 3 NPc 1 stroke 11 VM |
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Clinical Performance Scales | |||||||||||
Median FGA ± SD [points] | 29 ± 3 | 24 ± 5* | 21 ± 6* | 27 ± 4 | 17 ± 4* | 26 ± 4 | 26 ± 4 | 25 ± 5 | 23.9 | < 0.001 | |
Mean TUG ± SD [sec] | 8.8 ± 3.2 | 9.1 ± 2.3 | 11.2 ± 7.1 | 9.0 ± 2.0 | 13.7 ± 7.5 | 9.3 ± 2.6 | 9.9 ± 3.5 | 9.9 ± 6.5 | 2.0 | n.s | |
Median MOCA ± SD [points] | 29 ± 3 | 26 ± 4 | 24 ± 6* | 26 ± 3 | 24 ± 8* | 24 ± 4* | 29 ± 15 | 26 ± 9 | 2.9 | 0.008 | |
Subjective symptom scales | |||||||||||
Mean ABC-d ± SD [%] | 95 ± 9 | 70 ± 23* | 63 ± 22* | 79 ± 21* | 48 ± 28* | 84 ± 21* | 81 ± 25* | 76 ± 24 | 22.2 | < 0.001 | |
Median FES-I ± SD [points] | 17 ± 2 | 24 ± 9* | 31 ± 13* | 25 ± 8* | 42 ± 19* | 21 ± 7* | 31 ± 13* | 26 ± 12 | 19.1 | < 0.001 | |
Mean of SF-12 ± SD [points] physical domain | 54 ± 6 | 40 ± 9* | 38 ± 8* | 38 ± 10* | 33 ± 11* | 47 ± 10* | 40 ± 11* | 43 ± 11 | 26.6 | < 0.001 | |
Mean of SF-12 ± SD [points] psychological domain | 52 ± 9 | 48 ± 12 | 48 ± 11 | 44 ± 12* | 38 ± 13* | 47 ± 12 | 47 ± 10 | 47 ± 11 | 4.5 | < 0.001 | |
Retrospective falls epidemiology | df | p | |||||||||
No falls [%] | 90 | 58 | 34 | 81 | 14 | 74 | 46 | 60 | 12 | 104.5 | < 0.001 |
Occasional fall [%] | 7 | 23 | 23 | 15 | 9 | 11 | 27 | 17 | |||
Frequent falls [%] | 3 | 18 | 43 | 4 | 76 | 15 | 27 | 23 | |||
Retrospective falls severity | |||||||||||
Hopkins grade I [%] | 45 | 47 | 24 | 58 | 10 | 34 | 29 | 36 | 24 | 154.5 | < 0.001 |
II [%] | 27 | 27 | 49 | 29 | 35 | 53 | 58 | 40 | |||
III [%] | 27 | 13 | 15 | 11 | 20 | 0 | 0 | 12 | |||
IV [%] | 0 | 12 | 12 | 0 | 35 | 11 | 11 | 12 |
Sociodemographic, clinical information, and retrospective fall events (within 6 months) of the enrolled participants. Inter-subgroup differences are analyzed by ANOVA models with Sheffé post hoc comparisons (for sociodemographic and clinical data) and by procedures (fall data)
*Significant difference in the Sheffé post hoc comparison (compared to healthy subjects)
f female, m male, FGA functional gait assessment, FES-I falls efficacy scale-international, TUG timed-up-and-go test, MOCA Montreal Cognitive Assessment, SF-12 short form 12, BVP bilateral vestibular failure, UVP unilateral vestibular failure, SCA spinocerebellar ataxia, FRDA Friedreich ataxia, EA2 episodic ataxia type 2, DBN downbeat nystagmus syndrome, SAOA sporadic adult onset ataxia, ARAC autosomal recessive cerebellar ataxia, ACM tumor cerebellar, PPPD Persistent Phobic Postural Dizziness, FGD anxious functional gait disorder, CADASIL Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, SAE subcortical arteriosclerotic encephalopathy, BPPV benign paroxysmal positional vertigo, ED encephalomyelitis disseminate, HSP hereditary spastic paraplegia, NPc Niemann Pick Disease Type c, VM vestibular migraine