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. 2021 Aug 11;7:212. doi: 10.1038/s41420-021-00572-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The rat model of SCI was established, and rats were treated with EVs. The conditioned medium of HucMSCs treated with GW4869 was used as a control. A PKH26-labeled EVs in spinal cord tissues of rats were detected using immunofluorescence. B the motor function of rats in each group was evaluated by BBB scale on the 0, 7th, 14th, 21st, 28th day after the operation. C the pathological changes of spinal cord tissues were measured using HE staining on the 28th day after the operation. N = 6. Data are expressed as mean ± standard deviation and analyzed using two-way ANOVA, followed by Tukey’s multiple comparisons test, ***p < 0.001, Sham vs. SCI; ^###p < 0.001, GW vs. EVs.