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. 2021 Aug 11;12:4853. doi: 10.1038/s41467-021-24898-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a PK and SPK cells were analyzed for the expression of Smad4, PAK3, and JNK-Jun signaling-related factors by Western blotting and the experiment was repeated three times independently with similar results. b Western blots showing the effects of Smad4 overexpression in SPK cells and the experiment was repeated three times independently with similar results. c IHC staining detected the expression of Smad4, PAK3, p-JNK, and p-Jun in mouse lung tumors of PK and SPK mice. Scale bar, 25 μm (magnification, ×40). d Quantification of the average percentage of Smad4, PAK3, p-JNK, and p-Jun positive cells in mouse lung tumors of PK and SPK mice. Data presented are the mean ± SEM from three biologically independent samples (n = 3); *p = 0.001802131; **p = 0.007103699; ***p = 0.001259358; ****p = 0.000180321; as determined by two-tailed Student’s t-test.