Table 2.
Overview of the number of clusters of podocyte progenitors and mature podocytes with their respective markers discovered using single-cell RNA sequencing of developing human kidney.
| Author | Tissue age | Podocyte progenitor clusters | Markers early podocytes/ transitional cells | Podocyte clusters | Markers mature podocytes |
|---|---|---|---|---|---|
| Hochane, et al. 59 | w9, w11, w13, w16, w18 | 1 | OLFM3+/MAFB+/FOXC2+/CLIC5-LOW/ PTPRO-LOW, NPHS1-LOW, NPHS2-LOW | 1 | MAFB-LOW, NPHS2+, PTPRO+, PODXL+ |
| Lindstrom, et al. 66 | w17 | 1 | CLDN5+, OLMF3+ | 1 | TCF21+, NPHS2+ |
| Lindstrom, et al. 64 | w16 | 1 | PODXL+, MAFB+, NPHS2+ | 0 | N/A |
| Menon, et al. 61 | w12.4, w15, w15.7, w16.4, w18.8 | 1 | OLFM3+/MAFB-LOW | 1 | PODXL+, NPHS1+, NPHS2+, CLIC5+ |
| Combes, et al. 89 | w16 | 1 | ON1 CTGF+, OLFM3+, MAFB+, NPHS1+, LHX1-LOW, PAX8-LOW | 2 | PTPRO+, SYNPO+, VEGFA+, WT1+ |
| Tran, et al. 65 | w15, w17 | 1 | LHX1+, PAX8+, FBLN2+, OLFM3+, PCDH9+, SLC16A1+, GFRA3+, LEFTY1+ | 2 | PLA2R1+, ARMH4+, F3+, SYNPO+, NPHS2+, MAFB+, TGFBR3+, COL4A3+, COL4A4+, TNNT2+, PLCE1+, ANXA1+ |
| Wang, et al. 68 | w7, w8, w9, w10, w13, w19, w22, w24, w25 | 0 | N/A | 1 | N/A |
| Stewart, et al. 88 | w7-16 | 0 | N/A | 1 | NPHS2+, PTPRO+, WT1+, TCF21+, PODXL+ |
| Young, et al. 67 | w8,9 | 0 | N/A | 0 | N/A |
| Lindström, et al. 78 | w14 | 1 | EFNB2+, BMP4+, OLFM3+, MAFB+ | 1 | N/A |
w weeks, N/A information not available. Gene symbols in italic.