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. 2021 Aug 11;11:16323. doi: 10.1038/s41598-021-94933-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Renewal of corneal epithelial cells: Limbal early progenitor cells, late progenitor cells, basal, and transiently amplifying cells. (a) Violin plots of LPC-1 marker gene expression. SCANPY 1.7.1 in Python was used to generate violin plots as indicted in “Materials and methods” (https://pypi.org/project/scanpy/). (b) Topmost enriched MSigDB Canonical Pathways of genes differentially expressed between LPC-1 and 2. These top pathways correspond to genes down-regulated in LPC-1. The number of overlap genes are indicated next to each bar. RNAscope of selected markers from (a) on human cornea of (c) early limbal progenitor cells (LPC-1) GPHA2 and FRZB, (d) early and late limbal progenitor cells (LPC-1 and 2) MMP10, and (e) mixed basal or transiently amplifying cells (Epi-B1,B2) CSK2 and WNT10A (scale bar: 50 uM).