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. 2021 Aug 11;11:16323. doi: 10.1038/s41598-021-94933-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Molecular characteristics of conjunctival and corneal epithelial cells. (a) Heatmap of the top-most significantly differentially expressed genes between conjunctiva (Conj-1-3) and cornea (Epi-S1-3) that also overlap with cornea and conjunctiva comparison (from Fig. S6). RNAscope of selected markers from Fig. 4a. on human cornea of (b) KRT12 (red) as mature cornea epithelium marker and KRT13 (green) as conjunctiva marker, (c) conjunctival epithelial cell group Conj-1-3 genes KRT4, AQP5, and CEACAM7 (d) superficial mature corneal epithelial cell group Epi-S1-3 genes KRT3 and MAL, (e) cluster Conj-3 and Epi-S3 epithelial cell genes KRT24 and LYPD2 (scale bar: 50 uM). (f) Significant differentially expressed genes encoding cell junction proteins between groups conjunctival (Conj-1-3) and corneal (Epi-S1-3) epithelium. (g) Expression patterns of keratins KRT12, KRT13, KRT14, and KRT15 in the conjunctival and corneal epithelial cell clusters.