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. 2021 Aug 12;7:213. doi: 10.1038/s41420-021-00606-w

Fig. 1. Angiogenic signaling pathways are inhibited in the myocardium of MAP4 KI mice.

Fig. 1

A Representative bands of western blotting for detecting p-MAP4 in the myocardium; n = 5. B, C The statistical analysis of p-MAP4, and MAP4. ***p < 0.001 versus the Con group. N.S. represents no statistical difference between the Con and MAP4 KI groups; n = 5. D Representative immunoblotting bands of the levels of CD31, CD34, VEGFA, VEGFR2, ANG2, and TIE2 in the myocardium; n = 5. E–J The statistical analysis of CD31, CD34, VEGFA, VEGFR2, ANG2, and TIE2. ***p < 0.001 versus the Con-young group; ##p < 0.01 and ###p < 0.001 versus the Con-aged group; n = 5. K A scatter diagram showing the concentration of VEGF in the plasma. N.S. represents no statistical difference between the Con-young and MAP4 KI-young groups. ##p < 0.01 versus the Con-aged group; n = 8. L Representative TEM images of endothelial cells in the myocardium. Yellow arrows point to disrupted mitochondria. Scale bar, 0.5 µm; n = 3.