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. 2021 Aug 12;7:213. doi: 10.1038/s41420-021-00606-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Representative confocal images of CD31 in the myocardium. Scale bar, 10 µm; n = 3. Yellow arrows point to capillary. B Representative confocal images of lectin in the myocardium. Scale bar, 10 µm; n = 3. C A scatter diagram showing the statistical analysis of microvascular density in myocardium stained with CD31. N.S. represents no statistical difference between the Con-young and MAP4 KI-young groups. **p < 0.01 versus the Con-young group; ^###p < 0.001 versus the Con-aged group. D A scatter diagram showing the statistical analysis of red circles in myocardium stained with lectin. **p < 0.01 versus the Con-young group; ^###p < 0.001 versus the Con-aged group. E In vivo blood pressure measurement of WT and MAP4 KI mice at different ages. F Statistical analysis of Systolic pressure in (A). N.S. represents no statistical difference; n = 6. G Statistical analysis of Diastolic pressure in (A). N.S. represents no statistical difference; n = 6.