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. 2021 May 19;46(10):1734–1745. doi: 10.1038/s41386-021-01028-z

Fig. 3. Remifentanil effects on PrLC L5/6 pyramidal neuron excitatory and inhibitory transmission.

Fig. 3

Representative miniature excitatory postsynaptic current (mEPSC) traces from PrLC L5/6 pyramidal neurons in a males and b females following 14–21 days abstinence from 10–16 and 25–30 days of self-administration. c mEPSC frequency was significantly greater in saline females compared to 10–16- and 25–30-day remifentanil females as well as saline males. mEPSC frequency did not differ when comparing saline to 10–16-day or 25–30-day remifentanil males. d mEPSC amplitude was elevated in 25–30-day remifentanil mice compared to 10–16-day and saline mice. Representative miniature inhibitory postsynaptic current (mIPSC) traces in males (e) and females (f) following 14–21 days abstinence from 10–16 and 25–30 days of self-administration. g mIPSC frequency was greater in 10–16-day remifentanil females vs. saline and 25–30-day remifentanil females, with no differences between 25- and 30-day remifentanil and saline groups. No differences were observed when comparing saline males to 10–16- or 25–30-day remifentanil males. h Mean mIPSC amplitude was elevated in females compared to males regardless of treatment. Scale bars: 10 pA/100 ms. *p < 0.05, **p < 0.01, ***p < 0.001; +++p < 0.001 main effect of sex, ^p < 0.05 vs. Rem10-16, ##p < 0.01 vs Rem25-30.