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. 2021 Aug 11;12:4847. doi: 10.1038/s41467-021-24934-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a IP6K-mediated synthesis of the inositol pyrophosphates. PIP₂ phosphatidylinositol 4,5-bisphosphate, Ins inositol; the subscripts denote the total number of phosphates; PPIP5K diphosphoinositol pentakisphosphate kinase. b The chemical structure of SC-919. InsP₇ levels in the liver (c), muscle (d), and kidney (e) after 2 h of SC-919 administration to rats. Values indicate mean ± S.D. (n = 6 biological replicates). ^†P < 0.05 and ^‡P < 0.05 vs. vehicle as determined using Williams’ test and Shirley–Williams test, respectively. Veh vehicle.