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. 2021 Aug 11;12:4847. doi: 10.1038/s41467-021-24934-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Concentration of SC-919 and b plasma phosphate levels following the initial dose of SC-919 or sevelamer in adenine-treated rats. (n = 3 biological replicates for pharmacokinetics and n = 6 and 5 biological replicates for adenine-treated rats and normal rats for determination of phosphate levels in the plasma). c Concentration of SC-919 and d plasma phosphate levels following the seventh dose of SC-919 or sevelamer in adenine-treated rats. (n = 3 biological replicates for pharmacokinetics and n = 6 and 5 biological replicates for adenine-treated rats and normal rats for determination of phosphate levels in the plasma). e Concentration of SC-919 and f plasma phosphate levels in bilaterally nephrectomized rats that were orally administered with SC-919. Animals found dead during the study (1 rat in SC-919 1 mg/kg of e, 2 rats in nephrectomized-vehicle, and 1 rat in nephrectomized-SC-919 1 mg/kg of f. (n = 5–7 biological replicates for nephrectomzed rats, and n = 6 biological replicates for sham-operated rats for e and f). Values indicate mean ± S.D. ^†P < 0.05 and ^‡P < 0.05 vs. vehicle as determined using a Williams’ test and the Shirley–Williams test, respectively. Sev sevelamer.