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. 2021 Aug 11;7:210. doi: 10.1038/s41420-021-00596-9

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Several studies showed that there is an interaction between necroptosis, pyroptosis, and ferroptosis. RIP1 or RIP3-mediated necroptosis contributes to the membrane damage. Potassium ion outflow activates NEK7, which leads to the cleavage of GSDMD. Additionally, Iron activates ROS for GSDME-dependent pyroptosis in melanoma cells, suggesting there is a crosstalk between ferroptosis, pyroptosis and necroptosis.