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. 2021 Jul 29;15:685977. doi: 10.3389/fnins.2021.685977

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Copyright © 2021 Han, Seo, Choi, Lee and Park.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of the MRI-guided FUS system and experimental design. (A) The animal is in supine position with its head submerged in water tank. The focal area is targeted with MR image guidance and PC-controlled positioning system. (B) Experimental design for investigating the effects of FUS–BBBD on water transport. T2-weighted MR images were obtained to locate the focal region before the sonication, and T1-weighted images and diffusion tensor images were acquired for each time slot (5 min, 24 and 48 h) after the FUS–BBBD. Sprague–Dawley rats were sacrificed and perfused for staining after 48 h after the sonication.