FIGURE 12.

PTT of lung cancer and glioma. (A) IR1048-MZ as a novel NTR enzyme response single-molecule probe for NIR-Ⅱ hypoxia-activated PTT. (B) The absorption spectrum of IR1048-MZ when NTR is absent (black) and when NTR is present (blue). (C) Infrared thermal images of lung tumor-bearing mouse injected with saline or IR1048-MZ with or without 980 nm NIR laser irradiation (0.1 W cm⁻²) for 2 min. The room temperature is 23˚C. (D) Lung tumor growth curve after 30 days of different treatments. (E) Survival rate of lung tumor-bearing mice after various treatments (n = 5) (reproduced from (Meng et al., 2018) with permission from Ivyspring International Publisher). (F) Schematic diagram of NIR response to MoO₂ nano-aggregates and their PTT applications. (G) UV-vis-NIR absorption spectrum of MoO₂ nano aggregate surface-modified. (H) lung-tumor-bearing mouse and it’s tumors dissected after treatment, and tumor weights after 16 days of treatment (n = 5) (reproduced from (Guo, et al., 2020) with permission from Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature). (I) Schematic diagram of SPNs used in NIR-Ⅱ photothermal treatment of brain tumors. (J) Absorption spectra of SPNs in aqueous dispersion. (K) The infrared thermal image of the mouse during the 10-min PTT (1,064 nm, 1 W cm⁻²). Mice treated with PBS + laser were used as controls (reproduced from (Wen, et al., 2020) with permission from American Chemical Society).