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. 2021 Jul 29;12:722537. doi: 10.3389/fphar.2021.722537

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Copyright © 2021 Yang, Jiang, Wang, Wen, Mao, Lu, Zhang, Song and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In survival and non-survival groups, corticosteroid treatment decreased serum IL-18 (A). Changes of IL-18 after corticosteroid treatment (B). Corticosteroid treatment improved PaO₂/FiO₂ (C). Changes of PaO₂/FiO₂ after corticosteroid treatment (D). Corticosteroid treatment increased the neutrophil-to-lymphocyte ratio (E). APACHE II score at day 1, day 3, and day 7 (F).