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. 2021 Jul 29;12:673103. doi: 10.3389/fphar.2021.673103

FIGURE 2.

FIGURE 2

(A) Cisplatin exerted cytotoxicity on the normal cell line (HaCaT). (B) Cisplatin-treated CaSki cells showed significant reduction in cell viability in a dose and time dependent manner. (C) Percent cell viability of CaSki cells exposed to various doses of PEITC (5-30 μM) accompanied with 5 μM cisplatin compared to individual PEITC-treatment (5-30 μM). (D) Combined doses of PEITC with sub-optimal concentration of cisplatin (5 μM) exerted significant cytotoxic effects on CaSki cells. (E) CaSki cells were incubated with different concentration of PEITC (20, 25 and 30 μM) for 48 h, then nuclear condensation and fragmentation (white arrows) was detected by fluorescence microscopy. The data represents mean ±SD of three independent experiments. The image is the representation of three independent experiments. *p value < 0.05 compared with the untreated control was considered statistically significant.