Table 1.
Showing detailed information on selected EBV proteins investigated in this study.
| EBV proteins | Functions | Expression stage | Accession number | Residue count | References |
|---|---|---|---|---|---|
| BMRF2 | Viral entry, attachment to oral epithelial cells, manipulates cellular actin cell-to-cell spread | Lytic/structural | P03192 | 357 | [[132], [133], [134]] |
| BDLF2 | Interacts with BMRF2, rearranges cellular actin to promote viral cell-to-cell spread in epithelial cells | Lytic/structural | P03225 | 420 | [18,135] |
| BORF1 (Triplex Protein 1; TRX1) | Capsid assembly (minor capsid protein-binding protein; mCPBP). Required for efficient nuclear transport of Triplex protein 2 (TRX2) | Early lytic/structural | P03187 | 364 | [18] |
| BcLF1 | EBV capsid self-assembly (Major capsid protein; MCP) | Early lytic/structural | P03226 | 1381 | [18,136] |
| BDLF1 (Triplex Protein 2; TRX2) | minor capsid protein (mCP) required for capsid assembly in the nucleus | Early lytic/structural | P25214 | 301 | [136] |
| BFRF3 | Small capsomere-interacting protein (sCP) involved in capsid assembly | Early lytic/structural | P14348 | 176 | [18] |
| BXLF1 (EBV Thymidine kinase; TK) | Involved in the activation and re-activation of viral DNA replication | Early lytic | Q3KSQ2 | 607 | [123,137,138] |
| BGLF4 | Serine/threonine protein kinase. Mediates the phosphorylation of host nucleoporins. Enhances nuclear export of EBV lytic proteins, facilitates virion production | Early lytic | P13288 | 429 | [[138], [139], [140], [141], [142], [143], [144]] |
| BMRF1 | DNA polymerase processivity factor. Plays essential roles in lytic DNA activation and replication. Major phosphoryl target for BGLF4. Interacts with other EBV DNA-binding proteins | Early lytic |
P03191 PDB ID: 2Z0L |
404 | [83,[145], [146], [147], [148]] |