Table 2.
Characterization of predicted EBV B-cell epitopes based on their innate physicochemical properties.
| Physicochemical characterization | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Hydrophilicity |
Surface flexibility |
Surface accessibility |
Antigenicity |
Allergenicity |
|||||
| EBV proteins | Epitope | Score (Max/Min) | Epitope | Score (Max/Min) | Epitope | Score (Max/Min) | Epitope | Score (Max/Min) | AlgPred |
| BMRF2 | CARGDHS197-203 | 4.571 | LGSGSLA171-177 | 1.071 | RYKLKK320-325 | 10.315 | TVLVVCV225-231 | 1.3 | Non-allergenic |
| FFIFLAL165-171 | −7.414 | VVYMCCF336-342 | 0.876 | VLVVCV226-231 | 0.068 | AGARRNQ177-183 | 0.934 | ||
| BDLF2 | QDQNQNQ95-101 | 6.857 | DQNQNQT96-102 | 1.133 | QDQNQN95-100 | 4.805 | VFIYYCC190-196 | 1.253 | Non-allergenic |
| LAFLALL198-204 | −5.971 | RMAAMAP146-152 | 0.899 | CCYLAF195-200 | 0.070 | NRNRTFN298-304 | 0.868 | ||
| BORF1 | GGSGGGS73-79 | 5.929 | GGGSGGG72-78 | 1.142 | RRRLQR9-14 | 6.535 | VVHGPVV206-212 | 1.225 | Non-allergenic |
| LSLFILM129-135 | −6.071 | HCQIMNI286-292 | 0.892 | GGVCFV245-250 | 0.078 | GGGSGGG72-78 | 0.894 | ||
| BcLF1 | NGDHDHD785-791 | 6.700 | QKSNSPR1197-1203 | 1.115 | PRDRRE480-485 | 8.22 | VPLVSLC637-643 | 1.251 | Non-allergenic |
| IFYYVFL811-817 | −6.157 | IFYYVFL811-817 | 0.882 | ACVVSC1207-1212 | 0.052 | GNMDEMA767-773 | 0.869 | ||
| BDLF1 | STHGTQN33-39 | 5.386 | KLESNDV124-130 | 1.080 | KNKYQP94-99 | 8.702 | LKVVVSL3-9 | 1.227 | Non-allergenic |
| IVFPMVL132-138 | −5.129 | YFCIMVT208-214 | 0.883 | CIMVTL210-215 | 0.106 | RMRVMMT263-269 | 0.931 | ||
| BFRF3 | DTGSGGG155-161 | 6.357 | GSGGGGQ157-163 | 1.147 | DKRQRA75-80 | 4.673 | SYLVFLT46-52 | 1.151 | Non-allergenic |
| RSYLVFL45-51 | −3.214 | ASAAAAV148-154 | 0.912 | VAGAGA82-87 | 0.156 | DTGSGGG155-161 | 0.898 | ||
| BXLF1 | GEEDDDG54-60 | 8.143 | QKNGGKG204-210 | 1.126 | KKRGRK447-452 | 6.122 | VLLEVCL538-544 | 1.254 | Non-allergenic |
| VFPLMLL401-407 | −6.086 | LDCWILH385-391 | 0.880 | VLLEVC538-543 | 0.070 | GEEDDDG54-60 | 0.864 | ||
| BGLF4 | AEDGQDK127-133 | 6.757 | TNSSSSG12-18 | 1.155 | KKRFKE389-394 | 6.022 | VVLLEVL344-350 | 1.25 | Non-allergenic |
| VVLLEVL344-350 | −4.414 | YGIMHLA307-313 | 0.884 | AEVLAC349-354 | 0.117 | DTMWGMG207-213 | 0.867 | ||
| BMRF1 | SEPEDKS308-314 | 6.629 | RQQGSGG180-186 | 1.141 | RQKQKH387-392 | 6.086 | AHVVCSV237-243 | 1.249 | Non-allergenic |
| LSVILFN290-296 | −3.686 | CALMPYM143-149 | 0.899 | GIIAVV271-276 | 0.052 | TMEYDDK129-135 | 0.910 | ||