Figure 3.

Correlations between the proportion of Bmem in samples of PBMCs and serum 25(OH)D₃ in HCs and in patients with MS or NMOSD. A negative correlation between the percentage of Bmem and serum 25(OH)D₃ was found (A) in HCs regardless of the type of stimulation (i.e., steroid or 1,25(OH)₂D₃), and (B) in patients with MS only after stimulation of PBMCs with 1,25(OH)₂D₃. (C) In NMOSD, significant positive correlations were found after PBMC stimulation, with or without 1,25(OH)₂D₃. Linear regression lines indicate significant correlations. 1,25(OH)₂D₃, 1,25-dihydroxyvitamin D₃; Bmem, CD19⁺CD27⁺ memory B cell; HCs, healthy controls; MS, multiple sclerosis; NMOSD, neuromyelitis optica spectrum disorder; serum 25(OH)D₃, serum concentration of 1,25-dihydroxyvitamin D₃.