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. 2021 Jul 29;12:677041. doi: 10.3389/fimmu.2021.677041

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Copyright © 2021 Cho, Shin, Kwon, Kim, Seok, Kim and Min

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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There was a positive correlation between ΔC_T for CYP24A1 and serum 25(OH)D₃ in patients with MS. The mRNA expression level of CYP24A1 after stimulation with 1,25(OH)₂D₃ was lower in MS patients with higher serum 25(OH)D₃. 1,25(OH)₂D₃, 1,25-dihydroxyvitamin D₃; ΔC_T, difference in cycle threshold between that for the target gene and that for GAPDH; MS, multiple sclerosis; serum 25(OH)D₃, serum concentration of 1,25-dihydroxyvitamin D₃.