TABLE 1.
Basic characteristics of the studies included in the meta‐analysis
| Author | Region | Year | Sweetener | Age | N | Gender (male/female) | n | Gender (male/female) | Cancer | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | Case | Control | Case | Control | Case | Control | Case | Control | |||||
| Andreatta et al. (2008) | Argentina | 2008 | All | – | – | 197 | 397 | 156/41 | 267/130 | 51 | 87 | 39/12 | 37/50 | Urinary tract cancer |
| Gallus et al. (2007) | Italy | 2006 | Saccharine | 60 | 60 | 304 | 743 | 275/29 | 593/150 | 8 | 19 | – | – | Esophagus |
| Gallus et al. (2007) | Italy | 2006 | Saccharine | 62 | 58 | 1,953 | 4,154 | 1125/828 | 2073/2081 | 69 | 300 | – | – | Colorectum |
| Gallus et al. (2007) | Italy | 2006 | Saccharine | 61 | 61 | 460 | 1,088 | 415/45 | 863/225 | 17 | 29 | – | – | Larynx |
| Gallus et al. (2007) | Italy | 2006 | Saccharine | 55 | 56 | 2,569 | 2,588 | 0/2569 | 0/2588 | 113 | 120 | – | – | Breast |
| Gallus et al. (2007) | Italy | 2006 | Saccharine | 56 | 57 | 1,031 | 2,411 | 0/1031 | 0/2411 | 24 | 126 | – | – | Ovary |
| Gallus et al. (2007) | Italy | 2006 | Saccharine | 66 | 63 | 1,294 | 1,451 | 1294/0 | 1451/0 | 42 | 49 | – | – | Prostate |
| Gallus et al. (2007) | Italy | 2006 | Saccharine | 62 | 62 | 767 | 1,534 | 494/273 | 988/546 | 26 | 60 | – | – | Renal cell carcinoma |
| Howe et al. (1977) | Canada | 1977 | Saccharine | 67.8 | 68.9 | 455 | 455 | 455/0 | 455/0 | 58 | 36 | – | – | Bladder cancer |
| Najem et al. (1982) | US | 1982 | Saccharine | – | – | 75 | 142 | 65/10 | 130/20 | 12 | 19 | – | – | Bladder cancer |
| Momas et al. (1994) | France Mediterranean | 1994 | Saccharine | 67.8 | 65.0 | 219 | 792 | 219/0 | 792/0 | 30 | 52 | – | – | Bladder cancer |
| Goodman et al. (1986) | US | 1986 | saccharine | 20–80 | 20–80 | 266 | 266 | 189/77 | 189/77 | 73 | 61 | 47/26 | 41/20 | Renal cell cancer |
| Bosetti et al. (2009) | Italy | 2009 | Saccharine | 63 | 63 | 230 | 544 | – | – | 6 | 23 | – | – | Gastric cancer |
| Bosetti et al. (2009) | Italy | 2009 | Saccharine | 63 | 63 | 326 | 652 | – | – | 10 | 34 | – | – | Pancreatic cancer |
| Bosetti et al. (2009) | Italy | 2009 | Saccharine | 60 | 61 | 452 | 906 | – | – | 16 | 39 | – | – | Endometrial cancer |
| Møller‐Jensen et al. (1983) | Copenhagen | 1983 | Saccharine, cyclamate | 0–75 | 0–75 | 380 | 776 | 284/96 | 583/193 | 81 | 200 | 55/26 | 150/50 | Bladder cancer |
| Morrison et al. (1982) | UK | 1981 | Saccharine | – | – | 524 | 690 | 382/142 | 470/220 | 190 | 270 | 140/50 | 183/87 | Bladder cancer |
| Morrison et al. (1982) | Japan | 1981 | Saccharine | – | – | 289 | 576 | 223/66 | 432/144 | 126 | 321 | 100/26 | 238/83 | Bladder cancer |
| Ahmad et al. (2001) | Japan | 1991 | Saccharine | 68.2 | 68.2 | 261 | 521 | 195/66 | 389/132 | 50 | 99 | 40/10 | 72/27 | Urinary tract cancer |