TABLE 2.
Effect of plasticizer types and concentration on moisture content, solubility, WVP, and OP of USP films
| Film type | Moisture content (%) | Solubility (%) | WVP (g.mm−1s−1KPa−1 × 10–11) | OP (10−8cm3.cm/cm2.s.cmHg) |
|---|---|---|---|---|
| USP +30% Glycerol | 19.96 ± 0.4e | 49.4 ± 0.4e | 1.34 ± 0.01e | 1.49 ± 0.002c |
| USP +40% Glycerol | 24.16 ± 0.2c | 59.9 ± 0.2c | 1.93 ± 0.01c | 2.01 ± 0.001b |
| USP +50% Glycerol | 32.86 ± 0.2a | 67.2 ± 0.5a | 2.32 ± 0.002a | 2.98 ± 0.03a |
| USP +30% PEG 600 | 16.03 ± 0.1f | 43.16 ± 0.3f | 1.19 ± 0.009f | 7.45 ± 0.002f |
| USP +40% PEG 600 | 20.9 ± 0.1d | 54.13 ± 0.3d | 1.73 ± 0.02d | 7.84 ± 0.001e |
| USP +50% PEG 600 | 26.53 ± 0.4b | 61.13 ± 0.3b | 2.09 ± 0.005b | 8.04 ± 0.04d |
Values are given as mean ±standard deviation. Different letters in the same column indicate a statistically significant difference (p < .05).