Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 29;12:689270. doi: 10.3389/fimmu.2021.689270

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Kang, Feng, Luo, He, Liu, Wu and Rong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Potential functions of tertiary lymphoid structures in the TME. As in canonical SLOs, TLSs may constitute a critical site where specific T and B cells can undergo terminal differentiation into effector cells. GC B cells can differentiate into memory B cells and plasma cells in TLSs, and fully differentiated B cells and exert their antitumor effects. T cells can differentiate and expand, and they are activated as effector cells that exert cytotoxic effects. B cells and T cells in TLSs may interact with each other and play a synergistic role, which needs to be confirmed by more studies. Treg cells within TLSs could exert a negative influence on the capacity of TLSs to generate effector and memory lymphocytes.