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. 2021 Jul 29;11:681777. doi: 10.3389/fonc.2021.681777

Table 4.

Functional enrichment analysis.

Gene enrichment Terms Percent of genes (100%) P value
Cellular component Extracellular matrix 13.33 <0.001
Collagen type V 4.00 <0.001
Mitochondrial respiratory chain complex I 5.33 <0.001
Basement membrane 4.00 <0.001
Extracellular space 12.00 <0.001
Extracellular 28.00 <0.001
Molecular function Extracellular matrix structural constituent 13.98 <0.001
FAD binding 1.08 <0.01
Oxidoreductase activity 4.30 <0.01
Metallopeptidase activity 3.23 <0.05
Immunoglobulin receptor activity 1.08 <0.05
Transferase activity, transferring aldehyde or ketonic groups 1.08 <0.05
Biological process Metabolism 21.51 <0.001
Cell growth and/or maintenance 16.13 <0.001
Energy pathways 18.28 <0.01
Coenzyme and prosthetic group metabolism 1.08 <0.01
Synaptic transmission 1.08 <0.05
Mitochondrial transport 1.08 <0.05
Biological pathway Beta3 integrin cell surface interactions 12.20 <0.001
Epithelial-to-mesenchymal transition 19.51 <0.001
coenzyme A biosynthesis 4.88 <0.001
Respiratory electron transport 9.76 <0.01
Vitamin B5 (pantothenate) metabolism 4.88 <0. 01
Respiratory electron transport, ATP synthesis by chemiosmotic
coupling, and heat production by uncoupling proteins.
9.76 <0. 01