Table 2.

Antimicrobial prophylaxis in children undergoing allogeneic hematopoietic cell transplantation.

Phase	Antibacterial	Antiviral	Pnemocystis/toxoplasmosis	Antifungal	IVIG
Conditioning	NGR	NGR	NGR	NGR	NGR
Pre-engraftment	NGR	aciclovir	NGR	L-AmB, azoles or echinocandins	NGR
Post-engraftment w/o a/c GvHD	NGR	aciclovir	SMX/TMP	NGR	NGR
Post-engraftment with a/c GvHD	PNC	aciclovir	SMX/TMP	azoles or echinocandins	NGR

NGR, not generally recommended; PNC, penicillin; SMX/TMP, sulfamethoxazole/trimethoprim; L-AmB, intravenous liposomal amphotericin B; IVIG, intravenous immunoglobulin.

If IgG levels below 400 mg/dL IVIG could be given. a/c GvHD, acute or chronic graft vs host disease.