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. 2021 Jul 29;12:709342. doi: 10.3389/fgene.2021.709342

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Copyright © 2021 Divoux, Eroshkin, Erdos, Sandor, Osborne and Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Shared body shape differentially methylated sites between adipose tissue, cultured preadipocytes and whole blood (A,B). The 2 Venn diagrams depict the differentially methylated sites between 10 apple and 7 pear-shaped subjects in A (A) and GF (B) depot only in adipose tissue, only in preadipocytes or in both. Purple color depicts the number of unique genes annotated to sites hypermethylated in apple-shaped women. Blue color depicts the number of unique genes annotated to sites hypermethylated in pear-shaped women. (C) Pathway Analysis of the genes nearest the body shape specific DMS in A depot (A) and GF depot (GF). Only the common genes between whole tissue and cells were used. The size of the dots represents gene count. Only pathways with p-value < 0.05 are represented. (D) The Venn diagram depicts the common body shape DMS between adipose tissue, preadipocytes and blood for the 17 subjects. A = Abdominal, GF = Gluteo-femoral, DMS = Differentially Methylated Site.