. 2020 Oct 26;27(9):1364–1373. doi: 10.1177/1352458520966292

Table 1.

Demographics, clinical and MRI characteristics.

	Healthy controls	Low disability	High disability
Demographics
• Sex, F/M	52/30	135/50	30/7
• Age, years	45.93 (10.79)	43.83 (10.12)	52.94 (8.87)^a,b
• Disease duration		12.07 (7.27)	21.23 (8.55)^b
• Phenotypes (RRMS/SPMS), n		178/7	11/26^b
• EDSS Total^c		2.5 (0–3.5)	6.5 (6–8)^b
• FSS Cerebellar^c		1 (0–3)	3 (0–4)^b
• FSS Pyramidal^c		1 (0–3)	3 (2–5)^b
• FSS Sensory^c		2 (0–3)	2.5 (1–5)^b
• FSS Brainstem^c		0 (0–3)	1 (0–3)^b
• FSS Visual^c		0 (0–3)	1 (0–5)^b
• FSS Bowel and Bladder^c		0 (0–3)	2 (0–4)^b
• FSS Cerebral (mental)^c		1 (0–3)	2 (0–3)^b
Brain volumes
• NBV, L	1.51 (0.07)	1.48 (0.07)^a	1.40 (0.07)^a,b
• NWMV, L	0.69 (0.03)	0.67 (0.03)^a	0.65 (0.03)^a,b
• NCGMV, L	0.78 (0.05)	0.77 (0.05)^a	0.72 (0.06)^a,b
• NDGMV, mL	62.85 (3.75)	58.31 (5.80)^a	51.71 (7.10)^a,b
• Lesion volume (log), mL		3.88 (0.38)	4.25 (0.40)^b

MRI: magnetic resonance imaging; F: female; M: male; RRMS: relapsing-remitting multiple sclerosis; SPMS: secondary progressive multiple sclerosis; EDSS: Expanded Disability Status Scale; FSS: Functional Systems Scores; NBV: normalized brain volume; NWMV: normalized white matter volume; NCGMV: normalized cortical grey matter volume; NDGMV: normalized deep grey matter volume.

All values represent means and standard deviations unless denotes otherwise.

Significant difference compared to healthy controls.

Significant difference compared to patients with low disability.

Median and range.