Table 2.
Univariate and Multivariate Relationship of Cardiac Adipose Tissue Index and IL6 with outcomes at Day 21 in diabetic patients after admission for COVID-19
| Univariate analysis | Multivariate analysis* | |||||
|---|---|---|---|---|---|---|
| OR | 95% CI | (p) | OR | 95% CI | (p) | |
| Early mortality | ||||||
| Test of individual variables | ||||||
| CATi (continuous variable) | 1.01 | 1.003–1.02 | 0.006 | 1.01 | 1.001–1.02 | 0.033 |
| CATi (increased ≥ 130 ml/m2) | 6.15 | 1.96–19.3 | 0.002 | 5.20 | 1.46–18.38 | 0.011 |
| IL6 (continuous variable) | 1.06 | 1.03–1.09 | < 0.0001 | 1.05 | 1.02–1.09 | 0.001 |
| IL6 (increased ≥ 49 pg/ml) | 18.2 | 5.07–65.09 | < 0.0001 | 17.0 | 4.40–65.9 | < 0.0001 |
| Test of CATi + IL6 as covariates | ||||||
| CATi (continuous variable) | 1.02 | 1.01–1.04 | 0.003 | |||
| IL6 (continuous variable) | 1.07 | 1.03–1.12 | < 0.0001 | |||
| Test of integrated score CATi*IL6 | ||||||
| CATi*IL6 score (increased ≥ 6386) | 59.6 | 11.6–307.1 | < 0.0001 | 58.1 | 9.8–344.7 | < 0.0001 |
| ICU + Death | ||||||
| Test of individual variables | ||||||
| CATi (continuous variable) | 1.01 | 1.003–1.02 | 0.01 | 1.01 | 1.001–1.02 | 0.038 |
| CATi (increased ≥ 130 ml/m2) | 3.27 | 1.30–8.20 | 0.01 | 3.12 | 1.12–8.68 | 0.029 |
| IL6 (continuous variable) | 1.03 | 1.006–1.04 | 0.01 | 1.02 | 1.003–1.04 | 0.024 |
| IL6 (increased ≥ 49 pg/ml) | 4.86 | 1.75–13.51 | 0.002 | 4.59 | 1.58–13.38 | 0.005 |
| Test of CATi + IL6 as covariates | ||||||
| CATi (continuous variable) | 1.01 | 1.002–1.02 | 0.016 | |||
| IL6 (continuous variable) | 1.03 | 1.006–1.05 | 0.011 | |||
| Test of integrated score CATi*IL6 | ||||||
| CATi*IL6 score (increased ≥ 6386) | 7.96 (3.62) | 2.59–24.45 | < 0.0001 | 9.02 (3.49) | 2.62–31.06 | < 0.0001 |
*Multivariate logistic regression with adjustment for age, sex and BMI