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. 2021 Aug 3;22(4):703. doi: 10.3892/ol.2021.12964

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Copyright: © Hasegawa et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — YAP- or TAZ-dominant gastric cancer and VP treatment. (A) Kato III, NUGC-4 and MKN-74 cells exhibited a YAP-dominant expression pattern. MKN-45 cells demonstrated a TAZ-dominant expression pattern. VP significantly suppresses the proliferation of (B) MKN-45 cells compared with (C) MKN-74 cells at 24 h, and it took 72 h to achieve the same level of proliferation suppression in MKN-74 cells. (D) VP decreased the concentration of crystal violet in MKN-45 cells in a dose-dependent manner over 24 h. (E) The uptake of VP was faster in MKN-45 cells than MKN-74 cells. The CNT group was treated with an equal volume of DMSO. *P<0.05; **P<0.01 vs. control. CNT, control; DMSO, dimethyl sulfoxide; YAP, yes-associated protein; TAZ, transcriptional co-activator with a PDZ-binding domain; VP, verteporfin.