Figure 3.

VP treatment significantly decreases Survivin by suppressing YAP and TAZ expression. (A) VP treatment for 12 h decreases YAP in MKN-74 cells and TAZ in MKN-45 cells, as determined by western blotting. (B) The expression of downstream genes only Survivin is significantly decreased in MKN-45 cells at 24 h after VP treatment. (C) In MKN-74 cells, only Survivin is significantly decreased at 24 h after VP treatment. (D) Immunoblotting confirms that only Survivin expression is decreased at 24 h after VP administration. The CNT group was treated with an equal volume of DMSO. *P<0.05; **P<0.01 vs. control. CNT, control; DMSO, dimethyl sulfoxide; YAP, yes-associated protein; TAZ, transcriptional co-activator with a PDZ-binding domain; VP, verteporfin; CTGF, connective tissue growth factor; CYR61, Cysteine-rich angiogenic inducer 61.