Figure 5.

VP induces cell death and inhibits vascular mimicry in MKN-45 and MKN-74 cell lines. (A) Cell death is induced at 24 h after treatment with 15 µM VP, as shown by Annexin V and SYTOX green staining in MKN-45 and MKN-74 cells in a dose-dependent manner. (B) Vascular mimicry is suppressed at 72 h after treatment with 15 µM VP, as demonstrated by tube formation assays in MKN-45 and MKN-74 cells. The CNT group was treated with an equal volume of DMSO. **P<0.01 vs. control. CNT, control; DMSO, dimethyl sulfoxide; VP, verteporfin.