TABLE 3.

Biometric and echocardiographic parameters of the C57BL/6 gene knockout experimental mice.

	WT	WT + STZ	P2X7R–/–	P2X7R–/– + STZ
HR, bpm	460 ± 41	400 ± 63	460 ± 67	418 ± 54
HW/BW, mg/g	5.21 ± 0.27	6.59 ± 0.56**	5.38 ± 0.33	6.07 ± 0.58#
IVSD, mm	0.63 ± 0.04	0.64 ± 0.03	0.63 ± 0.08	0.63 ± 0.05
LVIDd, mm	3.55 ± 0.32	3.83 ± 0.24*	3.40 ± 0.36	3.60 ± 0.18# §§
LVPWd, mm	0.62 ± 0.06	0.69 ± 0.05*	0.63 ± 0.04	0.67 ± 0.06#
LVIDs, mm	2.23 ± 0.27	2.50 ± 0.35*	2.15 ± 0.25	2.39 ± 0.20##
EF%	76 ± 5.94	62 ± 7.59***	77.96 ± 4.85	71.23 ± 3.91### §§§
FS%	39.23 ± 5.26	28.8 ± 5.35***	40.63 ± 4.68	35.52 ± 2.66### §§§

HR, heart rate; HW/BW, heart weight/body weight; IVSD, diastole interventricular septal thickness; LVIDd, diastole left ventricle internal dimension; LVPWd, left ventricular diastole posterior wall thickness; LVIDs, systole left ventricle internal dimension; EF%, ejection fraction %; FS%, fractional shortening %.

Data presented as Mean ± SD, ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001, compared to WT; ^#p < 0.05, ^##p < 0.01, and ^###p < 0.001, compared to P2X7R^–/–; ^§§p < 0.01, and ^§§§p < 0.001, compared to WT + STZ.