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. 2021 Aug 5;22(4):711. doi: 10.3892/ol.2021.12972

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Copyright: © Wen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — METTL3 is significantly upregulated in CRC tissues compared with its expression levels in the corresponding adjacent normal colon tissues. (A) METTL3 mRNA expression levels in the human CRC cell lines, HT-29, HCT-116 and SW480, the normal cell lines NCM-460 and HIEC-6. (B) Relative mRNA expression levels of METTL3 in CRC tissues compared with those in the corresponding adjacent normal tissues (n=5). (C) Protein expression of METTL3 in CRC vs. the corresponding adjacent normal tissues. GAPDH was used as a loading control. The right panel shows the quantitative analysis of the western blot results, as analyzed by paired Student's t-test. (D) The expression of METTL3 in CRC and adjacent normal tissues was detected by IHC staining (magnification, ×100; n=5). Error bars represent standard deviation. *P<0.05, **P<0.01, ***P<0.001. METTL3, methyltransferase-like 3; CRC, colorectal cancer; P, patient; N, normal; T, tumor.