Table I.
Top 20 Upregulated genes in OC based on TCGA cohort.
| Gene | Gene ID | Median expression (tumor) | Median expression (normal) | Log2 (fold change) | Adjusted P-value |
|---|---|---|---|---|---|
| CLDN3 | ENSG00000165215.6 | 532.873 | 0.100 | 8.923 | 8.49e-227 |
| WFDC2 | ENSG00000101443.17 | 2341.633 | 4.850 | 8.645 | 9.12e-162 |
| SLPI | ENSG00000124107.5 | 1338.266 | 2.718 | 8.493 | 1.01e-125 |
| FOLR1 | ENSG00000110195.11 | 375.273 | 0.095 | 8.425 | 6.55e-143 |
| MSLN | ENSG00000102854.14 | 428.721 | 0.425 | 8.236 | 4.64e-138 |
| CD24 | ENSG00000272398.5 | 498.966 | 0.910 | 8.032 | 2.42e-158 |
| S100A1 | ENSG00000160678.11 | 505.318 | 1.180 | 7.860 | 4.29e-105 |
| CLDN4 | ENSG00000189143.9 | 265.56 | 0.460 | 7.512 | 6.91e-204 |
| LCN2 | ENSG00000148346.11 | 255.202 | 0.470 | 7.445 | 3.75e-96 |
| KRT7 | ENSG00000135480.14 | 364.872 | 1.130 | 7.425 | 3.60e-159 |
| SLC34A2 | ENSG00000157765.11 | 176.227 | 0.070 | 7.372 | 9.83e-121 |
| CDKN2A | ENSG00000147889.16 | 258.057 | 0.635 | 7.038 | 1.42e-83 |
| EPCAM | ENSG00000119888.1 | 246.893 | 0.755 | 7.142 | 9.65e-199 |
| KLK7 | ENSG00000169035.11 | 151.843 | 0.100 | 7.118 | 1.02e-112 |
| SMIM22 | ENSG00000267795.5 | 165.581 | 0.210 | 7.105 | 1.12e-139 |
| ELF3 | ENSG00000163435.15 | 237.617 | 0.785 | 7.063 | 3.96e-162 |
| KLK8 | ENSG00000129455.15 | 154.326 | 0.165 | 7.059 | 3.74e-152 |
| RNVU1-7 | ENSG00000206585.1 | 131.62 | 0.000 | 7.051 | 7.12e-27 |
| MAL2 | ENSG00000147676.13 | 153.974 | 0.210 | 7.001 | 3.04e-182 |
| KLK6 | ENSG00000167755.13 | 128.742 | 0.155 | 6.812 | 3.55e-94 |
Data were analyzed using the Gene Expression Profiling Interactive Analysis website. ELF3 is the 16th most upregulated gene in OC. Median value refers to the median expression value of the gene. OC, ovarian cancer.