Table 3.
The concentration of different subtypes of EVs in healthy controls and rheumatoid arthritis patients.
| EV concentration (106 EVs/l) | Healthy controls (n = 20) | Rheumatoid arthritis patients (n = 20) | p-value |
|---|---|---|---|
| PS+ EVs | 934.4 (695.6–1479.0) | 1918.0 (950.0.5–3822.0) | p = 0.01 |
| PEVs (CD42a+) | 218.1 (141.3–335.0) | 620.9 (202.2–1111.0) | p = 0.02 |
| TF+ EVs (CD142+) | 37.5 (26.2–48.7) | 50.3 (35.0–117.8) | p = 0.03 |
| LEVs (CD45+) | 53.4 (43.4–62.2) | 83.1 (62.2–145.3) | p = 0.008 |
| MoEVs (CD14+) | 74.7 (66.2–94.7) | 320.8 (235.0–527.5) | p < 0.001 |
| P-selectin (CD62P+) | 12.0 (10.0–19.4) | 20.0 (14.3–28.7) | p = 0.008 |
| EEVs (CD144+) | 35.0 (25.0–47.5) | 36.2 (26.8–72.2) | NS |
| E-selectin (CD62E+) | 33.1 (22.5–52.5) | 60.3 (18.7–106.6) | NS |
The results are expressed as median (IQR). NS, non-significant difference between the groups; EVs, extracellular vesicles; PS, phosphatidylserine; PEVs, platelet-derived EVs; LEVs, leucocyte-derived EVs; MoEVs, monocyte-derived EVs; EEVs, endothelial EVs.