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A). Canonical Polycomb-mediated transcriptional repression. EZH2 catalyzes the transfer of methyl group on H3K27, which can be recognized by CBX chromodomain, followed up with ubiquitylation on H2A119 by RING and downstream transcriptional repression. B). Polycomb group gene expression changes in tumor normalized to normal tissue. Using GEPIA, the gene expression fold changes across all tumor samples and paired normal tissues (T/N) were plotted as Log2 fold change in heatmap.
