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. 2021 Jul 29;9:716435. doi: 10.3389/fcell.2021.716435

FIGURE 1.

FIGURE 1

cMV levels according to successful aging in the 135 octogenarians included in the study. Results are shown as mean + SEM of concentrations of: (A) total microvesicles; (B) AV+ microvesicles; and (C) AV– microvesicles. Successful aging (n = 48) was defined as good functional (Barthel Index > 90 points, and Lawton Index scores > 7 for women and >4 men) and cognitive status (MEC > 24 points), and no need for institutionalization. Non-successful aging (NSA, n = 87) was further categorized in having one (NSA-1, n = 28), two (NSA-2, n = 23), or three scores (NSA-3, n = 36) below good functional and/or cognitive status (Barthel Index ≤ 90 points, Lawton Index scores ≤ 7 for women and ≤4 men, and/or MEC ≤ 24 points). AV indicates annexin V and cMV, circulating microvesicles. Used markers for MV phenotyping are shown in Supplementary Table 1. Columns with different superscript letters indicate significant differences (P < 0.05, Bonferroni post hoc test).