Fig. 3.

Significant fiber-specific reductions of whole-brain fixel-wise metrics in post-stroke aphasia compared to controls. A, Tract-specific streamlines represent mapped fixels with significantly reduced fiber density (FD), fiber density and bundle cross-section (FDC), and fiber-bundle cross-section (FC) values on the population-template, displayed as three-dimensional streamlines cropped from the template tractogram at FWE-corrected P < 0.05. B, Enlarged crossing-fiber areas with significant fixels of FD reductions. Left panels: colors are encoded by fixel direction (green: anterior-posterior, blue: superior-inferior, red: left–right); right panels: streamline points are colored by percentage reductions, and zoomed fixels are colored by FWE-corrected P-values. ATR = anterior thalamic radiation; CST = corticospinal tract; sCC = splenium of the corpus callosum; Tap = tapetum of the corpus callosum. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)