FIGURE 1.

The plasmablast signature includes 880 differential expressed genes compared with early B cells. (a) Pie chart of the number of up‐regulated and down‐regulated genes in murine plasmablasts (PB) compared with early B cells (including all B‐cell samples excepting plasma cells) based on the 882 gene signature. (b) Heatmaps of the signature score of murine genes according to their ontology and molecular function: cell surface receptor, reticulum endoplasmic (RE) stress and survival, transcription factor or immune signalling function. The genes mentioned in text are coloured in red for up‐regulated and in blue for down‐regulated genes. Row min and row max are minimal and maximal values for each row. (c) REVIGO representation of semantic association of gene ontology (GO) process significantly enriched in the murine molecular signature (FDR ≤ 0·05) (GO process enrichment test was performed with Gorilla)