Table 4. Rate of Decline for Episodic Memory, Perceptual Speed, and Mini-Mental State Examination Scorea.
| Characteristic | Standard deviation units (95% CI) | Difference, % | |
|---|---|---|---|
| Estimate | Difference | ||
| Episodic memory | |||
| Low tau concentration | |||
| Little physical activity | –0.021 (–0.049 to 0.006) | 1 [Reference] | 1 [Reference] |
| Medium physical activity | –0.029 (–0.053 to –0.005) | –0.008 (–0.033 to 0.018) | 38 |
| High physical activity | –0.015 (–0.037 to 0.007) | 0.007 (–0.019 to 0.032) | 33 |
| High tau concentration | |||
| Little physical activity | –0.035 (–0.073 to 0.003) | 1 [Reference] | 1 [Reference] |
| Medium physical activity | –0.009 (–0.043 to 0.026) | 0.026 (–0.007 to 0.060) | 74 |
| High physical activity | 0.0005 (–0.035 to 0.036) | 0.035 (0 to 0.071) | >100 |
| Perceptual speed | |||
| Low tau concentration | |||
| Little physical activity | –0.070 (–0.092 to –0.047) | 1 [Reference] | 1 [Reference] |
| Medium physical activity | –0.059 (–0.079 to –0.039) | 0.010 (–0.011 to 0.032) | 14 |
| High physical activity | –0.054 (–0.072 to –0.035) | 0.016 (–0.005 to 0.037) | 23 |
| High tau concentration | |||
| Little physical activity | –0.091 (–0.122 to –0.061) | 1 [Reference] | 1 [Reference] |
| Medium physical activity | –0.061 (–0.089 to –0.033) | 0.031 (0.004 to 0.057) | 34 |
| High physical activity | –0.061 (–0.089 to –0.032) | 0.031 (0.002 to 0.059) | 34 |
| Mini-Mental State Examination score | |||
| Low tau concentration | |||
| Little physical activity | –0.077 (–0.102 to –0.051) | 1 [Reference] | 1 [Reference] |
| Medium physical activity | –0.062 (–0.084 to –0.039) | 0.015 (–0.008 to 0.038) | 19 |
| High physical activity | –0.051 (–0.072 to –0.030) | 0.025 (0.002 to 0.049) | 32 |
| High tau concentration | |||
| Little physical activity | –0.077 (–0.118 to –0.037) | 1 [Reference] | 1 [Reference] |
| Medium physical activity | –0.030 (–0.069 to 0.009) | 0.047 (0.013 to 0.082) | 61 |
| High physical activity | –0.063 (–0.102 to –0.025) | 0.014 (–0.023 to 0.051) | 18 |
a
Physical activity: little activity (responded to at least 4 items and reported little activity for all responses), medium activity (<150 min/wk), and high activity (>150 min/wk). Total tau: low (≤0.40 pg/mL) and high (>0.40 pg/mL). All models adjusted for age, race/ethnicity, sex, educational level, chronic medical conditions, and apolipoprotein e4 and each of their interactions with time.