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. 2021 Jul 29;22(4):688. doi: 10.3892/ol.2021.12949

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — TNKS knockdown and DHA suppress activation of EMT and the Wnt/β-catenin pathway in gastric cancer. (A) Western blot analysis was performed to detect the expression levels of EMT- and Wnt/β-catenin pathway-related proteins in gastric cancer cells transfected with si-TNKS1/si-TNKS2 or treated with DHA. (B) TNKS, (C) AXIN2, (D) MMP2, (E) TWIST, (F) Vimentin, (G) β-catenin, (H) N-cadherin and (I) E-cadherin expression levels were quantified according to western blotting. ****P<0.0001 vs. the si-NC group; ^####P<0.0001 vs. the control group. TNKS, Tankyrases; DHA, Dihydroartemisinin; EMT, epithelial-to-mesenchymal transition; si, small interfering; MMP, matrix metalloproteinase; NC, negative control.