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. 2021 Jul 29;22(4):688. doi: 10.3892/ol.2021.12949

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — TNKS knockdown and DHA inactivate the Wnt/β-catenin pathway in gastric cancer. (A) Immunofluorescence analysis of TNKS, AXIN2 and β-catenin in HGC-27 and AGS gastric cancer cells treated with si-TNKS1/si-TNKS2, HLY78, DHA and HLY78 + HLY78. (B) TNKS, (C) AXIN2 and (D) β-catenin expression levels were quantified for HGC-27 cells. (E) TNKS, (F) AXIN2 and (G) β-catenin expression levels were quantified for AGS cells. *P<0.05, **P<0.01, ***P<0.001 and ****P<0.0001 vs. the si-NC group; ^##P<0.01, ^###P<0.001 and ^####P<0.0001 vs. the control group; ^&&&&P<0.0001 vs. the HLY78 group. TNKS, Tankyrases; DHA, Dihydroartemisinin; si, small interfering; NS, negative control.