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. 2021 Jul 29;11:691685. doi: 10.3389/fonc.2021.691685

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Copyright © 2021 Lewis, Karve, Matiash, Stone, Li, Wang, Versteeg, Aronow, Ahmad, Desai and Bogdanov

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hRabMab1 binds asTF with high affinity and has a favorable PK profile. Nine fully humanized antibodies were produced through mutagenesis of the heavy chain and light chain encoding vectors of the variable region of rRabMab1; HC3+LC3 was chosen for further analysis. (A) asTF binding kinetics of humanized RabMab1 antibodies compared to cRabMab1-hIgG1 as determined by AHC biosensor analysis. BDL indicates values were below instrument detection limit. (B) Western blot of Pt45.P1 lysates comparing the asTF detection ability of cRabMab1-hIgG1 and hRabMab1 (each diluted to 1 µg/mL); Silver stain of lysates. (C) Plasma levels of hRabMab1 resulting from a single injection of the antibody in C57Bl/6 mice. (D) PK analysis of hRabMab1.