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. 2021 Jul 29;11:691685. doi: 10.3389/fonc.2021.691685

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Copyright © 2021 Lewis, Karve, Matiash, Stone, Li, Wang, Versteeg, Aronow, Ahmad, Desai and Bogdanov

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcripts downregulated in hRabMab1-treated tumors are associated with a large number of PDAC-relevant biological functions and pathways. Network analysis was performed using ToppCluster, which is based on ToppGene’s genelist functions and annotations including GO categories, reactome pathways, protein-protein interactions, and Pubmed manuscript associations. Categories known to be associated with F3 (highlighted in yellow) also display a strong association with those gene function categories. Of particular interest, there is an extensive downregulation of focal adhesion, cell junction, and cell motility categories; in addition, downregulation of genes associated with positive regulation of proliferation is observed.