Table 1.

List of mouse to human cross-reactive molecules.

Murine Component	Human Component	Cross- Reactivity	Reference
TCRComplex
MHC Class I	TCR	Yes	43
MHC Class I	CD8	Yes	46
MHC Class II	TCR	Yes	43
MHC Class II	CD4	Yes	45
Cytokine Receptors
IL-2	IL-2R	Yes*	56
IL-3	IL-3R	No	21-26
IL-4	IL-4R	No	56, 85
IL-6	IL-6R	No	86
IL-7	IL-7R	Yes	54
IL-10	IL10-RA	?	n/a
IL-12	IL12R	Yes	87-88
IL-15	IL-15R	Yes	56
IL-17A	IL-17R	?	n/a
IL-23	IL23R	Yes	87-88
IFNα/β	IFNAR	No	99-100
IFNy	IFNGR	No	99-100
Type Ill Interferons	IFNLR1/IL10RB	Yes	101
M-CSF (CSF1)	M-CSFR (CD115)	No	21-26
GM-CSF (CSF2)	GM-CSFR (CD116)	No	21-26
G-CSF (CSF3)	G-CSFR (CD114)	Yes	21-26
TNFα	CD120a	Yes	21-26
FLT3L	FLT3	Yes	21-26
TGF-β	TGF-βR1-3	Yes	21-26
SCF	CD117	Yes	20
SDF-1	CXCR4	Yes	20
TNF Receptor Superfamily (TNFRSF)
OX40L (CD252)	OX40 (CD134)	?	n/a
FASL (CD178)	FAS (CD95)	?	n/a
CD70	CD27	?	n/a
4-1BBL (CD137L)	4-1BB (CD137)	?	n/a
CD40	CD40L (CD154)	?	n/a
Immunoglobulin Superfamily (lgSF
B7 (CD80/86)	CD28	Yes	128
B7 (CD80/86)	CTLA-4 (CD152)	Yes	128
PD-L1 (CD274), PD- L2 (CD273)	PD-1 (CD279)	?	n/a
ICOSL (CD275)	ICOS (CD278)	?	n/a